Prevalence of Rare Hemoglobin Variants Identified During Measurements of Hb A1c by Capillary Electrophoresis
نویسندگان
چکیده
منابع مشابه
Hemoglobin Camperdown [β104Arg→Ser] Detection During Hemoglobin A1c Measurement via Capillary Electrophoresis
Dear Editor, Reports on the analytical evaluation of capillary electrophoresis (CE) for glycated hemoglobin (HbA1c) measurement have already been published [1]. There have been several recent reports concerning the impact of the presence of hemoglobin variants on HbA1c measurement with the CE method. One study focused on the analytical interference of some hemoglobin variants [2], demonstrating...
متن کاملUse of Capillary Electrophoresis for Detection of Hemoglobinopathies in Individuals Referred to Health Centers in Masjed-Soleiman
Background: Hemoglobinopathies are the commonest single gene disorder in human that affect hemoglobin production and function that occur when mutations alter the amino acid sequence of globin chains. The purpose of the present study was to evaluate the prevalence of hemoglobninopathies detected by capillary electrophoresis method in individuals referred to Masjed-Soleiman health centers by capi...
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duction in neutrophils is induced by G-CSF, and NAP is released into the bloodstream, perhaps through leakage of ALP from damaged or dead neutrophils. Fossa et al. (9 ) reported leukocytosis and increased serum ALP in response to G-CSF treatment and suggested that increased serum ALP activity was related to release of the enzyme from the increased numbers of leukocytes. Neutrophils were reporte...
متن کاملTwo rare hemoglobin variants in the Çukurova Region of Turkey: Hb E-Saskatoon and Hb G-Coushatta.
Hb E-Saskatoon and Hb G-Coushatta are rare hemoglobin variants that are not a health problem. Herein we present a Turkish woman that was diagnosed as homozygous Hb E-Saskatoon (only the second such case reported from Turkey) and a Turkish boy diagnosed as heterozygote Hb E-Saskatoon. Additionally, 2 Turkish sisters diagnosed as heterozygote Hb G-Coushatta are presented.
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Measurement of glycohemoglobin (GHb) is an integral component of the management of patients with diabetes mellitus (1, 2). Glycation is the nonenzymatic addition of a sugar residue to amino groups of proteins. Numerous proteins in the body are glycated, but GHb in blood is the analyte most widely used clinically to monitor glycemic control. The concentration of GHb is directly proportional to t...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2017
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2017.276857